Stage IV cancers have spread beyond the breast and nearby lymph nodes to other parts of the body. When breast cancer spreads, it most commonly goes to the bones, liver, and lungs. It may also spread to the brain or other organs. Treatment options for stage IV breast cancer. treatment of Stage 4 hormone receptor positive breast cancer includes the systemic treatments such as chemotherapy in addition to anti-hormonal treatments. Stage 4 metastatic breast cancer should be thought of a chronic illness as the patient usually will receive many different courses of treatment over a long period of time.
Breast cancers commonly spread to lymph nodes (LNs). If the primary tumors are estrogen receptor (ER) and/or progesterone receptor (PR) positive, then the likelihood that LN metastases express receptors exceeds 80%. However, due to lack of ER+ models, little is known about the role of hormones in breast cancer spread or the effects of the LN microenvironment on hormone responsiveness. Metastatic, or stage 4, breast cancer means that your breast cancer has spread to another part of your body. It is still considered breast cancer because it originated in your breast. Being hormone receptor positive means your cancer cells have tested positive for estrogen receptors (ER) and/or progesterone receptors (PR), which have been shown.
Breast cancer cells taken out during a biopsy or surgery will be tested to see if they have certain proteins that are estrogen or progesterone receptors. When the hormones estrogen and progesterone attach to these receptors, they fuel the cancer growth. Cancers are called hormone receptor-positive or hormone receptor-negative based on whether or not they have these receptors (proteins). Apr 26, · Breast cancer is staged from 0 to 4. The stage reflects tumor size, lymph node involvement, and how far cancer may have spread. Other things, such as hormone receptor status and tumor grade, are Author: Ann Pietrangelo.
Sep 06, · Although at this point the cancer is incurable, a woman with stage 4 ER-positive breast cancer may respond well to hormone therapies that can extend life for many years. SurgeryAuthor: Ann Silberman.